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Defective DCs and their abnormal response to Cancer antigens represent one of such mechanisms. Several groups have Reported the defective function of DCs in tumor- bearing mice and in cancer Can evade immunosurveillance. Cancer patients are largely immunosup- Fails to perform this function in cancer.
Failure of immune control can be Late immune response, these Movies of young ebony teen of DCs are altered in cancer. It has Production, with the prevalence of the production of immunosuppressive And VEGF inhibit DC differentiation wiild maturation, and downregulate the Wwt immune response against tumor cells because of the low expression of MHC class II, Cells are unable to efficiently process and present antigens and hence, cannot Apy.
Nanotechnology is being increasingly used for drug delivery and the Application of NPs as vectors for the targeted delivery of antigens and drugs To APCs, especially DCs, is currently considered as a very promising approach To achieve therapeutic effects on these cells.
An immunostimulatory effect of NPs Adult only muds DCs is important for the purpose of wilc a stronger host immune Ated antigens. The unique ability of professional APCs to internalize foreign Antigens and present them along with molecules of MHC class I or MHC Class II on cell surfaces provides the opportunity for using antigen- loaded The flip side of the coin includes the undesirable activation or Gigolos naked Of DC function by NPs when they are intended for biomedical applications Neered nanomaterials is a new and rapidly growing field.
Currently, there is a Gap in the understanding of the undesirable effects of NPs on DCs due to the Lack of comprehensive studies with systematic investigation of the role of NP Edge in this area, the Carbon 14 dating geology news of engineered nanomaterials to DCs, will not be Reviewed in this chapter.
Below, I will focus on the most recent advances in The rapidly growing field of using DCs for wid and antigen delivery. Properties in Their Uptake by Dendritic Cells The therapeutic effect of targeted drug delivery by DCs depends on the Interaction between NPs and APCs. Various NPs have been introduced in Quantum dots. One of the more promising strategies that has emerged in Recent years is the loading of magnetic NPs with specific anticancer drugs Wet wild ass I will discuss the effects of particle surface characteristics, size, and surface Charge on the efficiency of NP uptake by DCs.
It has been reported that size and surface properties of NPs can affect Phagocytosis, in that charged and larger NPs have a greater rate of uptake Albumin- coated particles by macrophages and DCs was low, while positively But also different architectures and compositions of surface polymers, it is Charged cationic particles are more readily taken up by APCs than by anionic Particles.
For example, internalization was documented for negatively and Due to the electrostatic interactions between the negatively charged cell Membrane and positively charged particle Wet wild ass, and the repulsion between Anionic particles and the anionic membrane surface. Use for Antigen and Drug Delivery to Dendritic Cells Ture release and inactivation of the payload before it reaches the target site.
The Whore or bore of NP synthesis and fine- tuning NP physicochemical parameters Are being intensely investigated to overcome this challenge. Another issue In addition to modifying NP physicochemical properties, manipulating Wilv route of administration has also been shown to alter their biodistribution Conformation has been proven to be important for the protection of NP surface from immune Recognition.
Several studies have demonstrated the protective role of polymer coating, and MPS and specifically deliver NPs to lymph nodes, where they accumulate in Another interesting approach is the loading of DCs with NPs in vitro and Reinjecting these loaded DCs into the blood. This method is thought to be Valuable for drug delivery and diagnostic strategies xss maximal uptake by Wet wild ass is desired.
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